Stimuli-responsive nanomaterials for therapeutic protein delivery
نویسندگان
چکیده
منابع مشابه
Stimuli-Responsive Nanomaterials for Biomedical Applications
Nature employs a variety of tactics to precisely time and execute the processes and mechanics of life, relying on sequential sense and response cascades to transduce signaling events over multiple length and time scales. Many of these tactics, such as the activation of a zymogen, involve the direct manipulation of a material by a stimulus. Similarly, effective therapeutics and diagnostics requi...
متن کاملMulti-stage, charge conversional, stimuli-responsive nanogels for therapeutic protein delivery.
A boronate ester crosslinked zwitterionic nanogel (NGCA) with ATP/pH-sensitivity has been developed with an inverse nanoprecipitation technique to achieve a two-stage charge conversion that responds to tumor extracellular conditions (pH 6.5-6.8) and an intracellular acidic environment (pH 5-6). Cationic cytochrome C (CC), a therapeutic protein, has been encapsulated into NGCA through inverse na...
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Introduction Hydrogels have been extensively investigated as drug delivery carriers in biomedical applications.The stimuli-responsive hydrogel is generally created when an ionic monomer is incorporated into the hydrogel network, in which the charged group is formed and called fixed charge since its mobility is much less than that of freely mobile ions within the interstitial fluid. In this stud...
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Therapeutic proteins and peptides have become notable in the drug delivery arena for their compatibility with the human body as well as their high potency. However, their biocompatibility and high potency does not negate the existence of challenges resulting from physicochemical properties of proteins and peptides, including large size, short half-life, capability to provoke immune responses an...
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Diabetic therapeutics, including insulin and glucagon-like peptide 1 (GLP-1), are essential for diabetic patients to regulate blood glucose levels. However, conventional treatments that are based on subcutaneous injections are often associated with poor glucose control and a lack of patient compliance. In this review, we focus on the different stimuli-responsive systems to deliver therapeutics ...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2014
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2014.08.015